Madera Biosciences Careers in Rancho Santa Fe, CA

Madera BioSciences is a start-up biotechnology company focused on developing new small molecule drugs to treat Alzheimer’s disease (AD) via the clearance of beta amyloid from the CNS. Recent clinical data have shown that clearance of A beta is therapeutic in mild Alzheimer's disease and that treatment early in the disease process is optimal. These observations demonstrate that cost-effective small molecules - like those being developed by Madera - will be necessary for long-term treatment of AD patients. We are currently focusing on two programs that increase CNS expression of apolipoprotein E (ApoE), shown to clear pathogenic beta amyloid both in vitro in human systems and in animal models of Alzheimer's Disease leading to improved cognition and behavior.. Project 1: The potent and drug-like small molecule MAD8100 works via an unknown target to increase ApoE levels by human brain astrocytes. MAD8100 has very good bioavailability consistent with once-daily dosing and excellent brain